Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.
作者： Nicolas Zucchini , Gilles Bessou , Stephanie Traub , Scott H. Robbins , Satoshi Uematsu
DOI: 10.4049/JIMMUNOL.180.9.5799
关键词:
摘要: As initially demonstrated with murine cytomegalovirus (MCMV), plasmacytoid dendritic cells (pDCs) are the major source of IFN-alpha/beta in response to a variety viruses vivo. However, contradictory results have been obtained pertaining mechanisms promoting production by pDCs MCMV. In this study we show that TLR7 and TLR9 exert redundant functions for IFN-alpha/beta, IL-12p40, TNF-alpha vivo during MCMV infection. contrast, confirm systemic IL-12p70 strictly depends on TLR9. The combined loss recapitulates critical features phenotype MyD88-deficient mice, including dramatic decrease levels, an increase viral load, increased susceptibility MCMV-induced mortality. This is first demonstration implication recognition DNA virus.
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