BIOMECHANICS AND FUNCTION OF THE FEMALE RAT URETHRA IN STRESS URINARY INCONTINENCE INDUCED BY BIRTH TRAUMA

摘要: Stress urinary incontinence (SUI) is common in women after vaginal delivery (VD) childbirth or pelvic trauma, and may be associated with altered biomechanical functional properties of the urethra. The goal this dissertation was to identify changes urethra a rat model VD, as well understand role longitudinal smooth muscle healthy Female urethras were isolated SUI induced by VD. Controls from normal rats. Our established ex vivo urethral testing system utilized for pharmacological assessments. In system, outer diameter measured via laser micrometer, recorded along applied intraluminal pressure computer. Urethral thickness assessed histologically.Biomechancial markedly VD baseline, passive (via calcium chelation), active (stimulation adrenergic muscarinic receptors) states, most notably proximal Additionally, contractile responses phenylephrine bethanechol increased rats compared controls. There also mid segment. Functional parameters indicated that basal activity controls middle segment, at low strains. impaired tone distally controls, but only difference observed. had evidence collagen elastin. there lack PGP 9.5, tyrosine hydroxylase, vesicular acetylcholine transferase group. This suggests has mechanically damaging effects on innervation.Finally, further clarified modified system. Circumferential active, function supported idea longitudinally-oriented components lengthen shorten enable circumferential fully contract required. summary, provided damaged muscular, neural, matrix combination these contribute