Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers.

摘要: Abstract Background Reverse translating putative biomarkers of depression from patients to animals is complex because Major Depressive Disorder (MDD) a highly heterogenous condition. This review proposes an approach to reverse translation based on relating relevant bio-behavioural functions in laboratory rodents MDD symptoms. Methods systematic review outlines symptom clusters assessed by psychometric tests and antidepressant treatment response including the Montgomery–Asberg Depression Rating Scale, Hamilton Beck Inventory. Symptoms were related behavioural assays rodents. Results The resulting battery tests includes passive coping, anxiety-like behaviours, sleep, caloric intake, cognition, psychomotor functions, hedonic reactivity aversive learning. These are discussed alongside clinical symptoms MDD, providing framework through which reverse biomarker can be interpreted. Limitations Certain aspects may not quantified rodents, their biological significance always relevance. Conclusions Using this approach, it possible clarify functional hence translate its contribution specific symptoms, or