Autophagy: a key pathway of TNF-induced inflammatory bone loss.

摘要: Autophagy describes the degradation of unnecessary or dysfunctional cellular components through lysosomal machinery. is essentially required to prevent accumulation damage and ensure homeostasis. Indeed, impaired autophagy has been implicated in a variety different diseases. We examined role inflammatory bone loss. demonstrated that activated by pro-inflammatory cytokine tumor necrosis factor (TNF/TNFα) osteoclasts patients with rheumatoid arthritis (RA). induces osteoclast differentiation stimulates osteoclast-mediated resorption vitro vivo, thereby highlighting as novel mediator TNF-induced resorption.