Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses >2 cm in a hepatitis B virus-endemic area.

摘要: Background: Noninvasive criteria for diagnosing hepatocellular carcinoma (HCC) suggested by the American Association Study of Liver Diseases (AASLD) in 2005 consisted serum α-fetoprotein (AFP) level >200 ng/ml or a typical enhancement pattern (arterial and portal/delayed washed out) on dynamic imaging hepatic mass(es) >2 cm cirrhotic liver. Aims: To validate these Korean population to evaluate whether are applicable patients without cirrhosis at high risk developing HCC. Methods: We prospectively investigated 206 consecutive with who underwent biopsy surgical resection. Patients were evaluated four-phase computed tomography (CT) assays AFP concentrations baseline. classified according presence factors cirrhosis, diagnostic accuracy each test was determined. Results: The positive predictive values (PPV) CT findings 97.8% patients, 89.6% high-risk 82.4% low-risk patients. PPVs alone groups 98.8, 97.6 87.5% respectively. In addition levels minimally increased sensitivity from 81.6 87.8% but reduced PPV 89.6%. Conclusions: Serum concentration is not suitable criterion HCC. Typical can be used diagnose HCC both cirrhosis.