Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor
作者： Anna Challa , Winnie Chan , Richard J Krieg Jr , Mohamed Alaa Thabet , Frances Liu
DOI: 10.1038/KI.1993.372
关键词:
摘要: Effect of metabolic acidosis on the expression insulin-like growth factor and hormone receptor. To further our understanding failure in acidosis, we examined (IGF-I IGF-II), IGF binding protein-3 (IGFBP-3), hepatic mRNA receptor control, pair-fed acidotic rats. The rats last group were made by using ammonium chloride (1.5%) as their sole fluid intake for eight days. Metabolic was confirmed a blood pH 7.11 ± 0.10 (mean SD). mean starting weights all 167.1 3.4 grams. Growth impairment observed after one week intake. body compared to those control 155.5 18.9 g versus 222.8 9.7 g, P ad libitum controls, same IGF-I concentrations significantly decreased animals (P
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