Psychosocial Stress, Catecholamines, and Essential Fatty Acid Metabolism in Rats

摘要: To examine the effects of psychosocial stress and "stress hormone," epinephrine, on essential fatty acid metabolism in rats, two studies were conducted. In first, four weeks (i) social isolation (ii) group housing (control) liver microsomal delta 6 5 n-6 desaturase activity studied group-reared male normotensive (Wistar Kyoto) spontaneously hypertensive (SHR) rats (n = 5/group). The second study examined acute ip epinephrine (0.0, 1.0, 2.0, 4.0 mg/kg) hr prior to following an ig dose (4 g/kg) safflower oil (rich 18:2n-6, LA) plasma LA, 20:4n-6 (AA), LA/AA ratios adult deficient Sprague-Dawley 6/group). first experiment, significantly inhibited (P < 0.05) 0.01) SHR 0.05). study, increased LA at doses 1.0 2.0 mg/kg most fractions examined, suppressed AA levels. response ratio varied between tissues among lipid fractions, but this moderate (2.0-4.0 cases. These data suggest that stressors are capable inhibiting rate limiting steps is more pronounced than Wistar Kyoto. They also altering vivo acids rat.