miR clusters target cellular functional complexes by defining their degree of regulatory freedom.

摘要: Using the two paralog miR-23∼27∼24 clusters as an example and combining experimental clinical data in a systematical approach to microRNA (miR) function dysregulation, complex picture of their roles cancer is drawn. Various findings appear be contradictory larger extent cannot fully explained by classical regulatory network models feedback loops that are mainly considered one-to-one interactions involved molecules. Here, we propose extended model role miRs that, at least, supplements usually single/oligo-target regulation certain miRs. The cellular availability participating miR members this reflects upper hierarchy level intracellular extracellular environmental influences, such neighboring cells, soluble factors, hypoxia, chemotherapeutic drugs, irradiation, among others. novel based on understanding functional complexes, for apoptosis, migration, proliferation. These complexes consist many components can targeted cluster different but may affect ways. We final miR-related effect result possible degree freedom provided effects whole structure. This defines which react response triggers, also understood sensitization (more options) or de-sensitization (less system rather than single