A New Orally Active Quaternary Ammonium, Ganglion Blocking Drug Capable of Reducing Blood Pressure, SU-3088

摘要: Experiments were performed in animals to evaluate 4,5,6,7-tetrachloro-2-(2 dimethylaminoethyl)-isoindoline dimethochloride, (Su-3088), as an orally effective ganglion blocking drug. These demonstrated reduction of blood pressure, suppression vasopressor reflexes and potentiation the pressor action epinephrine. Neostigmine deblocked drug effects returned responses toward normal. patients produced warming extremities delay gastric emptying. Preliminary trial a treatment for hypertension suggested that may be useful. It has long period action, 12 hours or more small dose requirement, 50 100 mg.