Design and Evaluation of Celecoxib Porous Particles using Melt Sonocrystallization

摘要: The purpose of the article was to study melt sonocrystallization (MSC) for a drug forming viscous when processed below its glass transition temperature. A molten mass poured in vessel containing deionized water, maintained at 40°C using cryostatic bath, and sonicated 1 min probe ultrasonicator an amplitude 80% cycle 0.8 per second. product obtained after solidification dispersed droplets separated by filtration dried room MSC celecoxib characterized solubility determination, scanning electron microscopy, differential calorimetry, X-ray powder diffraction, stability study. technique designed celecoxib, which undergoes fast solidification. particles were porous, irregular shape, amorphous nature. An increase apparent observed particles. These also exhibited higher state as compared with quenching. reported demonstrates advantages over other approaches can be exploited area particle design amorphization drugs.