Slowed peak resting frequency and MEG overactivation in survivors of severe sepsis and septic shock.

摘要: Abstract Objective Survivors of severe sepsis and septic shock suffer from residual cognitive impairments, which persist even years after intensive care unit (ICU) discharge. As the awareness long-term consequences gradually grows, research has focused on impairments via questionnaires, but only few have structural or electrophysiological features, such as peak resting frequency, is commonly seen a hallmark brain function. Methods We aimed to analyze progression activity in terms frequency power survivors. Healthy individuals with no history ICU stay served controls. Data were collected three times (shortly, 6 12 months discharge) survivors Participants also underwent behavioral neuropsychological assessment. Results Sepsis exhibited significantly higher spectral dominant peak, was shifted towards lower frequencies. Within one year, increased level controls, did not decrease. observed close correlation between mental status. Conclusions support assumption causal relationship oscillations performance. Significance suggest that postseptic shift due abnormal thalamocortical dynamics.