Heterocyclic modulators of tgr5 for treatment of disease

作者: Anthony B. Pinkerton , Mark R. Herbert , Dana L. Siegel , Ayman Kabakibi

DOI:

关键词:

摘要: Disclosed herein are compounds useful as modulators of TGR5 and methods for the treatment or prevention metabolic, cardiovascular, inflammatory diseases.

参考文章(12)
Taisuke Tawaraishi, Hiroshi Imoto, Nobuo Cho, Fused ring compound ,(2008)
Anima Maruti Majestic Apartment Bollaram Road Baruah, Dibyendu De, Christopher W. Alexander, Jennepalli Sreenu, Indu Dager, Sivaram Pillarisetti, Santanu Maitra, Ish Kumar Khanna, Novel benzylamine derivatives as cetp inhibitors ,(2005)
Peter Nickolaus, Horst Dollinger, Domnic Martyres, Birgit Jung, Juergen Mack, Substituted pteridines for the treatment of inflammatory diseases ,(2005)
David George GlaxoSmithKline Allen, Diane Mary GlaxoSmithKline Coe, Caroline Mary GlaxoSmithKline Cook, Michael Dennis GlaxoSmithKline Dowle, Christopher David Edlin, Julie Nicole GlaxoSmithKline Hamblin, Martin Redpath Johnson, Paul Spencer GlaxoSmithKline Jones, Mika Kristian Lindvall, Charlotte Jane GlaxoSmithKline Mitchell, Alison Judith Redgrave, Naimisha GlaxoSmithKline Trivedi, None, Pyrazolo ’3,4-b! pyridine compounds, and their use as phosphodiesterase type 4 (pde4) inhibitors ,(2005)
Yasuchika Yamaguchi, Neil Moorcroft, Bernd Kaiser, Raymond F. Horvath, Ping Ge, Stanly John, Greg Shutske, Kevin J. Hodgetts, 5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds ,(2004)
Paul William GlaxoSmithKline Smith, Roderick Alan GlaxoSmithKline Porter, Compounds having activity at nk3 receptor and uses thereof in medicine ,(2005)
Carlo Farina, Giuseppe Arnaldo Maria Giardina, Marisa Martinelli, Stefania Gagliardi, Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists ,(2002)
Yuji Kawamata, Ryo Fujii, Masaki Hosoya, Masataka Harada, Hiromi Yoshida, Masanori Miwa, Shoji Fukusumi, Yugo Habata, Takashi Itoh, Yasushi Shintani, Shuji Hinuma, Yukio Fujisawa, Masahiko Fujino, A G Protein-coupled Receptor Responsive to Bile Acids Journal of Biological Chemistry. ,vol. 278, pp. 9435- 9440 ,(2003) , 10.1074/JBC.M209706200
Hongyu Liao, Patricia Lopez, Nuria A. Tamayo, Fang-Tsao Hong, Seifu Tadesse, Substituted heterocyclic compounds and methods of use ,(2005)
Jonathan Mark Argenta Discovery Limited Sutton, Mark Richard Ashton, David Edward Argenta Discovery Limited Clark, Robert Alexander Pharmagene Lab. Ltd. Coleman, Kenneth Lyle Pharmagene Lab. Ltd. Clark, Shirley Ann Brunton, Keith A. J. Argenta Discovery Limited Stuttle, Garry Argenta Discovery Limited Fenton, Neil Victor Argenta Discovery Limited Harris, George Argenta Discovery Hynd, Richard Jon Pharmagene Lab. Ltd. Davis, Edward Andrew Boyd, Alexander William Pharmagene Lab. Ltd. Oxford, Ep2- receptor agonists ,(2005)