Dimensión respiratoria de la escala ALSFRS-R y la función respiratoria en la esclerosis lateral amiotrófica

摘要: Virtually all patients with amyotrophic lateral sclerosis will complain of dyspnea, which is perhaps the most distressing symptom this devastating disease. The objective was to correlate respiratory domain ALSFRS-R forced vital capacity and maximal static pressures in mouth. We designed a prospective study 20 consecutive without dyspnea during 24 months. global decline from 34.3 +/- 10.3 22.1 8.0 (p = 0.0325), contribution irrelevant. Those who referred (n: 12), fell 41 21% initial value but similar fall (46 23%) 8 did not dyspnea. Total score correlated (litres), r: 0.73, p 0.0016 inspiratory pressure (cm H2O), 0.84, 0.0038, (%) (r(s): 0.23, 0.1400). There moderate correlation between (%), r(s): 0.58, 0.0300 expiratory 0.49, 0.0400. concluded that functional deterioration could be predicted using ALSFRS-R. This suggests scale does replace function testing measurements and, due insufficiency clinically evident; performing pulmonary tests provides an view permit make anticipatory actions.