Novel mutations in the calcium sensing receptor gene in tropical chronic pancreatitis in India.
作者： Elango E. Murugaian , Ram Mohan R. Premkumar , Lakshmi Radhakrishnan , Balakrishnan Vallath
DOI: 10.1080/00365520701580413
关键词:
摘要: Objective. Tropical chronic pancreatitis (TCP) is a form of seen in many tropical countries young non-alcoholic subjects who are often malnourished. Nutritional deficiencies, either at the macro or micro level, and food toxins have been implicated its causation, although there no final proof to confirm this suggestion. Mutations SPINK1 CFTR genes proposed as disease modifiers, determinants phenotypes. involving calcium sensing receptor (CASR) suggested increase risk (CP), since high intracellular levels activate trypsinogen within acinar cells. A combination CASR gene mutations has predispose idiopathic CP. The purpose study was report on novel CASR, identified TCP patients. Material methods. We screened our patients for genes. In cohort 35 an equivalent number con...
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