Sub-chronic administration of brewed coffee on rat behavior and cognition and oxidative stress Alzheimer's disease model

摘要: Summary Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by intracellular neurofibrillary tangles and neuro-inflammation. Growing experimental evidence indicate diverse biological effects of brewed coffee (BC) including antioxidant, neuroprotective anti-inflammatory. However, the underlying mechanism BC still largely elusive. Keeping this in mind, present study was aimed to investigate on STZ-induced AD. We observed that path length latency time increased STZ induced AD while administration enhanced these indices BC-STZ group. After treatment with BC, times groups memory impairment shuttle box MWM tasks. Biochemical factors lipid peroxidation marker tumor necrosis factor-α ameliorated these. Total anti-oxidant concentration level has reduced rats otherwise, prevented its reduction. Our demonstrated pretreatment significantly improved spatial learning functions, effectively mitigated ICV-STZ mediated neuronal oxidative stress neurobehavioral functions. Moreover, attenuated hippocampal neuro-inflammatory response hippocampus. Thus, our further provides for therapeutic supplementation various disorders