5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent

作者: Colin P. Spears , Bengt G. Gustavsson

DOI:

关键词:

摘要: The present invention relates to the compound 5,10-methylene-tetrahydrofolate (CH 2 FH 4 ), and its solution product isomer , therapeutic uses of these compounds, compositions thereof. CH strongly modulate in vivo antitumor effects 5-Fluorouracil.

参考文章(46)
Judith K. Sato, Edward M. Newman, Richard G. Moran, Preparation of (6R)-tetrahydrofolic acid and (6R)-5-formyltetrahydrofolic acid of high stereochemical purity. Analytical Biochemistry. ,vol. 154, pp. 516- 524 ,(1986) , 10.1016/0003-2697(86)90024-2
Martin Poe, L. M. Jackman, Stephen J. Benkovic, 5,10-Methylene-5,6,7,8-tetrahydrofolate. Conformation of the tetrahydropyrazine and imidazolidine rings. Biochemistry. ,vol. 18, pp. 5527- 5530 ,(1979) , 10.1021/BI00591A041
Verne Schirch, William B. Strong, Interaction of folylpolyglutamates with enzymes in one-carbon metabolism Archives of Biochemistry and Biophysics. ,vol. 269, pp. 371- 380 ,(1989) , 10.1016/0003-9861(89)90120-3
R. G. Moran, C. P. Spears, C. Heidelberger, Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 1456- 1460 ,(1979) , 10.1073/PNAS.76.3.1456
Mehran Goulian, Bruce M. Bleile, Lisa M. Dickey, Robert H. Grafstrom, Holly A. Ingraham, Scott A. Neynaber, Mark S. Peterson, Ben Y. Tseng, Mechanism of thymineless death. Advances in Experimental Medicine and Biology. pp. 89- 95 ,(1986) , 10.1007/978-1-4684-1248-2_15
Kenneth T. Douglas, The thymidylate synthesis cycle and anticancer drugs Medicinal Research Reviews. ,vol. 7, pp. 441- 475 ,(1987) , 10.1002/MED.2610070405
Susan B. Horwitz, Gregory Kwok, Leslie Wilson, Roy L. Kisliuk, Diastereoisomers of formaldehyde derivatives of tetrahydrofolic acid and tetrahydroaminopterin Journal of Medicinal Chemistry. ,vol. 12, pp. 49- 51 ,(1969) , 10.1021/JM00301A013
Arnold Lockshin, Peter V. Danenberg, Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochemical Pharmacology. ,vol. 30, pp. 247- 257 ,(1981) , 10.1016/0006-2952(81)90085-X
Daniel V. Santi, Charles S. McHenry, Ronald T. Raines, Kathryn M. Ivanetich, Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase. Biochemistry. ,vol. 26, pp. 8606- 8613 ,(1987) , 10.1021/BI00400A017