Balancing forces: architectural control of mechanotransduction
作者： Christopher C. DuFort , Matthew J. Paszek , Valerie M. Weaver
DOI: 10.1038/NRM3112
关键词:
摘要: All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations mechanotransduction, from nanoscale-level tissue-level, compromises tensional homeostasis promote pathologies such as cardiovascular disease cancer. The mechanisms suggest that complex interplay exists between extracellular cellular function. Furthermore, sustained disruptions caused by alterations matrix, allowing it serve mechanically based memory-storage device perpetuate or restore normal tissue behaviour.
nature.com
sci-hub.se 参考文章(110)
Dan P. Felsenfeld, Pamela L. Schwartzberg, Ana Venegas, Richard Tse, Michael P. Sheetz, Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nature Cell Biology. ,vol. 1, pp. 200- 206 ,(1999) , 10.1038/12021
Harvey F. Lodish, Molecular Cell Biology ,(1986)
John S. Condeelis, Jeffrey E. Segall, Jeffrey B. Wyckoff, Joan G. Jones, A Critical Step in Metastasis: In Vivo Analysis of Intravasation at the Primary Tumor Cancer Research. ,vol. 60, pp. 2504- 2511 ,(2000)
Roland Kaunas, Phu Nguyen, Shunichi Usami, Shu Chien, None, Cooperative effects of Rho and mechanical stretch on stress fiber organization Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15895- 15900 ,(2005) , 10.1073/PNAS.0506041102
Karen Reiser, Richard J. McCormick, Robert B. Rucker, Enzymatic and nonenzymatic cross-linking of collagen and elastin. The FASEB Journal. ,vol. 6, pp. 2439- 2449 ,(1992) , 10.1096/FASEBJ.6.7.1348714
I. Varga, G. Hutóczki, M. Petrás, B. Scholtz, E. Mikó, A. Kenyeres, J. Tóth, G. Zahuczky, L. Bognár, Z. Hanzély, A. Klekner, Expression of invasion-related extracellular matrix molecules in human glioblastoma versus intracerebral lung adenocarcinoma metastasis. Central European Neurosurgery. ,vol. 71, pp. 173- 180 ,(2010) , 10.1055/S-0030-1249698
Valerie M Weaver, Sophie Lelièvre, Johnathon N Lakins, Micah A Chrenek, Jonathan C.R Jones, Filippo Giancotti, Zena Werb, Mina J Bissell, β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell. ,vol. 2, pp. 205- 216 ,(2002) , 10.1016/S1535-6108(02)00125-3
Viola Vogel, Michael Sheetz, Local force and geometry sensing regulate cell functions Nature Reviews Molecular Cell Biology. ,vol. 7, pp. 265- 275 ,(2006) , 10.1038/NRM1890
R. J. Pelham, Y.-l. Wang, Cell locomotion and focal adhesions are regulated by substrate flexibility Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 13661- 13665 ,(1997) , 10.1073/PNAS.94.25.13661
Yasuhiro Sawada, Masako Tamada, Benjamin J. Dubin-Thaler, Oksana Cherniavskaya, Ryuichi Sakai, Sakae Tanaka, Michael P. Sheetz, Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas Cell. ,vol. 127, pp. 1015- 1026 ,(2006) , 10.1016/J.CELL.2006.09.044