Pathology of Bioabsorbable Implants in Preclinical Studies.

摘要: Bioabsorbable implants can be advantageous for certain surgical tissue bioengineering applications and implant-assisted repair. They offer the obvious benefits of nonpermanence eventual restoration native tissue's biomechanical immunological properties, while providing a structural scaffold healing route additional therapies (i.e., drug elution). present unique developmental, imaging, histopathological challenges in conduct preclinical animal studies interpretation pathology data. The bioabsorption process is typically associated with gradual decline (over months to years) strength integrity may also cellular responses such as phagocytosis that confound efficacy safety end points. Additionally, these bioabsorb, they become increasingly difficult isolate histologically thus imaging modalities microCT very valuable determine original location assess remodeling response tandem histopathology. In this article, we will review different types bioabsorbable commonly used materials; additionally, address some most common pitfalls confronting histologists pathologists collecting, handling, preparing tissues through histology, evaluating, interpreting study data implants.