Cytomegalovirus infection after bone marrow transplantation: an association with acute graft-v-host disease.

摘要: Among 181 patients undergoing allogeneic bone marrow transplantation over a five-year period (1978 through 1982), cytomegalovirus (CMV) infection was frequent and often lethal complication. Recipient pretransplant serology the most important predictor of posttransplant CMV infection. occurred in 26/137 seronegative recipients 28/44 seropositive (P less than .001). who developed infection, time to identical (median, 71 days post transplant). Bone donor did not significantly influence rate. strongly associated with acute graft-v-host disease (AGVHD), occurring 34/81 AGVHD 20/100 without GVHD preceded by 33.7 (mean) developing both complications. Patients infections had also received more cellular blood products transplant. These data suggest that may occur reactivation latent virus (in recipients) or exogenous exposure, possibly transfused products, but duration immunoincompetence be critical route exposure timing clinically evident Prophylaxis tailored likely infectious source effective prevention preventing after transplantation.