Adhesion Receptors in Allergic Disease

摘要: The inflammatory process in allergic disease is characterized by a distinct pattern of leukocyte accumulation, particular increased numbers activated eosinophils, T-lymphocytes, and monocytes with relative paucity neutrophils. Leukocyte migration through endothelium has been shown to be staged which the cells are initially lightly tethered under flow conditions roll along its surface. This followed cell activation, thought mediated soluble chemotactic stimulus that allows firmer bond develop between leucocyte endothelial cell, results successful adhesion transmigration (Fig. 1) (1). steps occur series so each essential for occur. means selectivity can introduced at steps, resulting considerable diversity signals any one site. It also modulated offering range targets pharmacological inhibition.