Humanized mice in translational biomedical research
作者： Leonard D. Shultz , Fumihiko Ishikawa , Dale L. Greiner
DOI: 10.1038/NRI2017
关键词:
摘要: The culmination of decades research on humanized mice is leading to advances in our understanding human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology regenerative medicine. In this Review, we discuss the development these new generations mice, how they will facilitate translational several biomedical disciplines approaches overcome remaining limitations models.
nature.com
mh-hannover.de
sci-hub.se 参考文章(139)
B E Torbett, T J Kipps, G R Picchio, M B Kirven, R Kobayashi, D E Mosier, S M Baird, J L Garnier, EBV-induced human B cell lymphomas in hu-PBL-SCID mice. AIDS Research and Human Retroviruses. ,vol. 8, pp. 735- 740 ,(1992)
F Pflumio, B Izac, A Katz, LD Shultz, W Vainchenker, L Coulombel, Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells. Blood. ,vol. 88, pp. 3731- 3740 ,(1996) , 10.1182/BLOOD.V88.10.3731.BLOODJOURNAL88103731
Karen Ann Pauwelyn, Catherine M. Verfaillie, Transplantation of Undifferentiated, Bone Marrow‐Derived Stem Cells Current Topics in Developmental Biology. ,vol. 74, pp. 201- 251 ,(2006) , 10.1016/S0070-2153(06)74007-8
N Kawano, F Ishikawa, K Shimoda, M Yasukawa, K Nagafuji, T Miyamoto, E Baba, T Tanaka, S Yamasaki, H Gondo, T Otsuka, K Ohshima, L D Shultz, K Akashi, M Harada, Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/β2-microglobulinnull mice Leukemia. ,vol. 19, pp. 1384- 1390 ,(2005) , 10.1038/SJ.LEU.2403829
Eric J. Wagar, Mandy A. Cromwell, Leonard D. Shultz, Bruce A. Woda, John L. Sullivan, RuthAnn M. Hesselton, Dale L. Greiner, Regulation of Human Cell Engraftment and Development of EBV-Related Lymphoproliferative Disorders in Hu-PBL- scid Mice Journal of Immunology. ,vol. 165, pp. 518- 527 ,(2000) , 10.4049/JIMMUNOL.165.1.518
Nicolas Legrand, Kees Weijer, Hergen Spits, Experimental Models to Study Development and Function of the Human Immune System In Vivo Journal of Immunology. ,vol. 176, pp. 2053- 2058 ,(2006) , 10.4049/JIMMUNOL.176.4.2053
Tsvee Lapidot, Mechanism of Human Stem Cell Migration and Repopulation of NOD/SCID and B2mnull NOD/SCID Mice Annals of the New York Academy of Sciences. ,vol. 938, pp. 83- 95 ,(2006) , 10.1111/J.1749-6632.2001.TB03577.X
Stephan Ellmerich, Marcin Mycko, Katalin Takacs, Hanspeter Waldner, Faisal N Wahid, Rosemary J Boyton, Rosalind HM King, Paul A Smith, Sandra Amor, Amy H Herlihy, Rachel E Hewitt, Mark Jutton, David A Price, David A Hafler, Vijay K Kuchroo, Daniel M Altmann, None, High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model Journal of Immunology. ,vol. 174, pp. 1938- 1946 ,(2005) , 10.4049/JIMMUNOL.174.4.1938
Toshiyuki Takaki, Michele P. Marron, Clayton E. Mathews, Stephen T. Guttmann, Rita Bottino, Massimo Trucco, Teresa P. DiLorenzo, David V. Serreze, HLA-A*0201-Restricted T Cells from Humanized NOD Mice Recognize Autoantigens of Potential Clinical Relevance to Type 1 Diabetes Journal of Immunology. ,vol. 176, pp. 3257- 3265 ,(2006) , 10.4049/JIMMUNOL.176.5.3257
I B Schweitzer, B Tennent, S McKenna, L Mobraaten, P A Schweitzer, B Gott, S W Christianson, D L Greiner, T V Rajan, L D Shultz, Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. Journal of Immunology. ,vol. 154, pp. 180- 191 ,(1995)