Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery.
作者： Isabela Cristina Aguiar de Souza , Leticia Villafranca Faro , Carlos Basilio Pinheiro , Daniel Tadeu Gomes Gonzaga , Fernando de Carvalho da Silva
DOI: 10.1039/C6DT02456D
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摘要: Three novel cobalt(iii)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2enMe2) on electronic reactivity their was observed. An [O2]-dependent reduction to cobalt(ii) by ascorbic acid provided evidence hypoxic selectivity.
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