Aromatic amines and cancer

摘要: Epidemiological evidence on the relation between aromatic amines and cancer risk is reviewed. In particular, in humans resulting from exposure to occupational sources tobacco smoking assessed with reference ecologic, cohort, case-control studies. Seven arylamines have been classified by International Agency for Research Cancer: benzidine-based dyes MOCA (4,4'-methylene bis 2-choloroaniline) were considered 'probably' carcinogenic, Group 2A, because of a high level experimental animals; two chemicals (2-naphthylamine benzidine), one drug (Chlornaphazine), manufacturing processes (manufacture auramine magenta) included 1 basis 'sufficient' carcinogenicity humans. Occupational exposures explain up 25 percent bladder cancers some areas Western countries; these estimates might be higher limited developing countries. Aromatic contaminate ambient air as component environmental smoke. There increasing that excess smokers attributable rather than other contaminants smoke such polycyclic hydrocarbons (PAH). A modulating role associated played metabolic polymorphisms, N-acetyltransferase genotype, raising important social ethical issues. The consistent observation difference men women risk, after allowing known factors, suggests consideration gender-related biological determinants future investigation.