The effect of prednisolone on canine neutrophil function: in vivo and in vitro studies.
作者： G. Trowald-Wigh , L. Håkansson , A. Johannisson , L.E. Edqvist
DOI: 10.1186/BF03547793
关键词:
摘要: The in vivo effect of a therapeutic dose prednisolone on canine neutrophil adherence, random migration, chemotaxis, phagocytosis IgG and C3b opsonized yeast cells, chemiluminescence, Fc- CR3-receptor expression was investigated. Prednisolone also added vitro to neutrophils as isolated cells whole blood. In the study, increased mediated ingestion number activated assay, while flow cytometric investigation IgG-receptor Fc gamma RIII with monoclonal antibody showed similar before, during after treatment. C3b-opsonized CR3-receptors (CD11b CD18) measured by cytometry unchanged. Chemiluminescence chemotactic response towards zymosan serum were increased, adherence nylon wool decreased. studies revealed that had no or dampening cell suspensions. Adherence well decreased at highest concentration (800 ng/ml) present study suggests part antiinflammatory corticosteroids through their influence neutrophils, besides reduced may be exerted clearance microorganisms IgG-complexes an elevated functional capacity.
biomedcentral.com
sci-hub.st 参考文章(31)
WC Liles, DC Dale, SJ Klebanoff, Glucocorticoids inhibit apoptosis of human neutrophils Blood. ,vol. 86, pp. 3181- 3188 ,(1995) , 10.1182/BLOOD.V86.8.3181.3181
Gunilla Trowald-Wigh, Kerstin Thorén- Tolling, Chemiluminescence and chemotaxis assay of canine granulocytes: a methodological study. Acta Veterinaria Scandinavica. ,vol. 31, pp. 79- 86 ,(1990) , 10.1186/BF03547580
Gunilla Trowald-Wigh, Kerstin Thorén-Tolling, Phagocytosis induced by yeast cells in canine granulocytes: a methodological study. Acta Veterinaria Scandinavica. ,vol. 31, pp. 87- 95 ,(1990) , 10.1186/BF03547581
Edward C. Feldman, Richard W. Nelson, Canine and Feline Endocrinology and Reproduction ,(1987)
Peter C. Wilkinson, Chemotaxis and inflammation ,(1974)
J A Roth, M L Kaeberle, Effects of in vivo dexamethasone administration on in vitro bovine polymorphonuclear leukocyte function Infection and Immunity. ,vol. 33, pp. 434- 441 ,(1981) , 10.1128/IAI.33.2.434-441.1981
T.R. Phillips, W.C. Yang, R.D. Schultz, The effects of glucocorticosteroids on the chemiluminescence response of bovine phagocytic cells Veterinary Immunology and Immunopathology. ,vol. 14, pp. 245- 256 ,(1987) , 10.1016/0165-2427(87)90093-6
J.F. Guelfi, M.K. Courdouhji, M. Alvinerie, P.L. Toutain, In vivo and in vitro effects of three glucocorticoids on blood leukocyte chemotaxis in the dog. Veterinary Immunology and Immunopathology. ,vol. 10, pp. 245- 252 ,(1985) , 10.1016/0165-2427(85)90050-9
Katsuya Inada, Masami Ogasawara, Miyuki Suzuki, Teruo Kirikae, Kazuhiro J. Mori, Masao Yoshida, Enhancement of in-vitro granulopoiesis and induction of differentiation of M1 cells by a glucocorticoid-dependent factor produced from P388D1 cells Leukemia Research. ,vol. 12, pp. 305- 314 ,(1988) , 10.1016/0145-2126(88)90045-8
W.A. Colburn, C.R. Sibley, R.H. Buller, Comparative serum prednisone and prednisolone concentrations following prednisone or prednisolone administration to beagle dogs Journal of Pharmaceutical Sciences. ,vol. 65, pp. 997- 1001 ,(1976) , 10.1002/JPS.2600650711