Cognitive function during early abstinence from opioid dependence: a comparison to age, gender, and verbal intelligence matched controls

摘要: Individuals with opioid dependence have cognitive deficits during abuse period in attention, working memory, episodic and executive function. After protracted abstinence consistent deficit has been found only However, few studies explored function first weeks of abstinence. The purpose this study was to individuals early It hypothesized that are pronounced immediately after peak withdrawal symptoms passed then partially recover. Fifteen patients fifteen controls matched for, age, gender, verbal intelligence were tested a test battery When performed worse than correlations between performance days withdrawal, duration abuse, any substance or symptom inventory score (Short Opiate Withdrawal Scale) analyzed. Early abstinent dependent statistically significantly tests measuring complex function, fluid intelligence. Their memory performances correlated withdrawal. results indicate rather general neurocognitive higher order cognition. is suggested from related induced neural dysregulation the prefrontal cortex partly transient.