Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis.

摘要: Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms involved in the formation maintenance of vascular network embryonal post-natal life. It has long been known that endothelial Ca2+ signals are key players remodeling; indeed, multiple pro-angiogenic factors, including growth factor, regulate cell fate through an increase intracellular concentration. Transient Receptor Potential (TRP) channel consist a superfamily non-selective cation channels widely expressed within cells. In addition, TRP present two main progenitor (EPC) populations, i.e., myeloid angiogenic cells (MACs) colony forming (ECFCs). polymodal can assemble homo- heteromeric complexes may be sensitive to both cues subtle changes local microenvironment. These features render most versatile entry pathway EPCs. Herein, we describe how stimulate remodeling by promoting angiogenesis, vasculogenesis integration environmental, e.g., extracellular factors chemokines, intracellular, reactive oxygen species, decrease Mg2+ levels, or hypercholesterolemia, stimuli. illustrate induce neovascularization response synthetic agonists small molecule drugs. We focus attention on TRPC1, TRPC3, TRPC4, TRPC5, TRPC6, TRPV1, TRPV4, TRPM2, TRPM4, TRPM7, TRPA1, were shown vasculogenesis. Finally, discuss role aberrant tumor vascularization focusing TRPV2, TRPM8, TRPA1. observations suggest potential therapeutic targets disorders featured abnormal vascularization, cancer, ischemic disorders, retinal degeneration neurodegeneration.