Chromosome studies in preleukemia. I. Aneuploidy of group C chromosomes in three patients.

摘要: Three patients with different obscure hematologic disorders are presented. All 3 had abnormalities of chromosome number confined to marrow cells. Case 1 is a 23-year-old man aplastic anemia; most his bone cells contained 45 chromosomes, one missing from group C. 2 62-year-old who died idiopathic sideroachrestic 47 chromosomes an extra C which appeared be autosome. 59-year-old woman thrombocythemia; while the majority her 46 stable minority cell line 48 chromosomes. Although many reported myelodysplastic-myeloproliferative have normal 5 cases some chromosomal aberration, previously by others, summarized. None these clinical evidence leukemia. In 4 patients, anomaly involved in C, aneuploidy occurred all our patients. It postulated that stable, aneuploid stem does not itself produce neoplasia, but rather this alteration genome may provide more favorable milieu for action transforming agent. Because frequent occurrence disorders, it further genes on or might responsible homeostatic control hemopoiesis, and change genetic balance involving chromosome(s) coupled agent result leukemia greater proportion individuals than other group.