Long-term effects of cyclosporine on renal function in liver transplant recipients.

摘要: The long-term effects of cyclosporine on renal function were evaluated in eleven liver transplant recipients over a 6–26-month follow-up period. Renal hemodynamic (glomerular filtration rate [GFR], effective plasma flow [ERPF])* fell 60% postoperatively, subsequently improved, and stabilized at 45–60% normal despite continued drug administration. Tubular sodium transport studies during water diuresis suggested that the proximal tubule is major site nephrotoxicity. In contrast to acute function, fraction glomerular filtrate reabsorbed was less patient group 'while fractional excretion sodium, potassium, phosphate increased. When filtered diluting segment examined as delivery, functional impairment occurred well. Eight biopsies performed six patients 4–29 months posttransplantation showed only mild moderate changes, predominantly vascular, which correlated poorly with corresponding function. These data administration produced early persistent depression both tubular A rather than structural mechanism appears be more significant this period observation.