Simple Adherence Assessments to Predict Virologic Failure among HIV-Infected Adults with Discordant Immunologic and Clinical Responses to Antiretroviral Therapy

摘要: Abstract We evaluated the association between two antiretroviral therapy (ART) adherence measurements—the medication possession ratio (MPR) and patient self-report—and detectable HIV viremia in setting of rapid service scale-up Lusaka, Zambia. Drug outcomes were assessed a subset patients suspected treatment failure based on discordant clinical immunologic responses to ART. A total 913 included this analysis, with median time 744 days (Q1, Q3: 511, 919 days) from ART initiation viral load (VL) measurement. On aggregate over period follow-up, 531 (58%) had optimal (MPR ≥95%), 306 (34%) suboptimal 80–94%), 76 (8%) poor <80%). Of patients, 238 (26%) VL ≥400 copies/ml when tested. When compared individuals adherence, there was increasing risk for virologic those [adjusted relative (ARR): 1.3; 95% confidence interval (CI):...