Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines
作者： Hisahiro Kai , Ena Akamatsu , Eri Torii , Hiroko Kodama , Chizuko Yukizaki
DOI: 10.1007/S11418-011-0510-5
关键词:
摘要: Adult T-cell leukaemia (ATL) is caused by human virus type I (HTLV-I) infection and resistant to conventional chemotherapy. We evaluated the inhibitory effects of agricultural plants on proliferation seven ATL-related cells, using three ATL cell lines (ED, Su9T01 S1T), two transformed HTLV-I (HUT-102 MT-2) HTLV-I-negative acute lymphoblastic (Jurkat MOLT-4). A total 52 samples 80% ethanol extracts obtained from 30 types were examined. On basis IC(50) values, we selected with greater activity than genistein, which was used as a positive control. The highest effect observed leaves Vaccinium virgatum Aiton (blueberry) four Su9T01, HUT-102 Jurkat); seeds Momordica charantia L. (bitter gourd) exhibited second activity. bitter gourd suppressed (Su9T01, Jurkat). edible parts Ipomea batatas LAM. (sweet potato), Colocasia esculenta (L.) Schott (taro), skin taro Prunus mume Sieb. et Zucc. (mume) showed markedly genistein. These findings suggest that ATL-preventative bioactive compounds may exist in these plants, are considered be functional foods.
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