Heart Mitochondria: Receivers and Transmitters of Signals

摘要: Besides their central bioenergetic role in supplying ATP, heart mitochondria play an essential the regulatory and signaling events that occur response to physiological stresses, including but not limited failure (HF), myocardial ischemia reperfusion injury (IRI), hypoxia, oxidative stress (OS), hormonal cytokine stimuli. Research on both intact cardiac skeletal muscle tissue cultured cardiomyocytes has just begun probe nature extent of mitochondrial involvement interorganelle communication, hypertrophic growth, cell death. In this chapter we will discuss participation, at molecular biochemical levels, multiple interrelated pathways, gauging effect have as a receiver, integrator, transmitter signals phenotype.