摘要: Striatal medium-sized spiny neurons contain high levels of soluble guanylyl cyclase (sGC), 3′-5′-cyclic guanosine monophosphate (cGMP)-dependent protein kinase and other components the cGMP signaling system. sGC-cGMP is activated by gaseous neuromodulator nitric oxide (NO). A growing body literature indicates that under physiological conditions, NO-producing interneurons are potently glutamate dopamine (DA). The complex nature modulatory effects NO on striatal likely depends effector pathways recruited during relative activity subtype study. Indeed, a review electrophysiological studies exerts variety local circuit projection involved in regulating basal ganglia output motor behavior. In addition to summarizing these influences, this chapter discusses impact DA depletion examines relevance nitrergic dysregulation for pathophysiology Parkinson's disease.
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