Prenatal stress produces sex differences in nest odor preference.

摘要: Prenatal stress (PS) and early postnatal environment may alter maternal care. Infant rats learn to identify their mother through the association between care familiar odors. Female Wistar were exposed restraint for 30 min, 4 sessions per day, in last 7 days of pregnancy. At birth, pups cross-fostered assigned following groups: prenatal non-stressed mothers raising (NS:NS), stressed (S:NS), (NS:S), (S:S). Maternal behaviors assessed during 6 postpartum days. On day (PND) 7, behavior male female was analyzed odor preference test; noradrenaline (NA) activity olfactory bulb (OB) measured. The results showed that increased plasma levels corticosterone on gestational 15. After parturition, PS reduced care, decreasing licking increasing frequency outside nest. from NS:S, S:NS, S:S groups group no nest preference. Thus, at submitted perinatal interventions more impairment test than pups. No changes detected NA OB. In conclusion, repeated week gestation reduces a rat sex-specific manner.