p53 alterations in myeloid leukemia.
作者： Anita Boyapati , Eiki Kanbe , Dong-Er Zhang
DOI: 10.1159/000074489
关键词:
摘要: Although most solid tumors contain inactivating mutations of the p53 tumor suppressor, hematological malignancies do not frequent alterations in gene (<20%). How these arise presence a super suppressor like remains to be elucidated. Given number downstream effectors p53, it is likely that critical targets are inactivated leukemia, bypassing requirement for tumors. This review describes new biochemical and transcriptional activities as well status acute myelogenous leukemia chronic leukemia.
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