Protein kinase C inhibitors for immune disorders
作者： Amnon Altman , Kok-Fai Kong
DOI: 10.1016/J.DRUDIS.2014.05.008
关键词:
摘要: Protein kinase C (PKC) proteins are a group of well-conserved, intracellular signaling enzymes expressed in all cells and tissues, including immune cells. Much the molecular insight into PKC immunobiology has been gleaned from studies using gene (Prkc) knockout mice analysis different disease models these animals. More-recent have revealed that PKCs also crucial roles pathogenesis human disorders. Therefore, strategies to modulate functions could major impact on treatment therapies autoimmune diseases other
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