Classification of canine nonangiogenic, nonlymphogenic, gastrointestinal sarcomas based on microscopic, immunohistochemical, and molecular characteristics.

摘要: Canine nonangiogenic, nonlymphogenic, gastrointestinal sarcomas have been previously diagnosed as stromal tumors (GIST), leiomyosarcomas, or nonspecified spindle cell sarcomas, but diagnostic criteria for each entity are poorly defined. We propose a classification canine based on microscopic, immunohistochemical, and molecular characteristics. Applying the to 40 documented its prognostic value. Eighteen (45%) were classified GIST positive KIT immunoreactivity. All GISTs vimentin, 14 (78%) S-100, 6 (33%) smooth muscle actin (SMA). In contrast their human counterparts, occurred mainly in small intestine (67%) commonly metastasized (5/18) liver, lymph nodes, omentum. Six had an activated mutation exon 11 of c-Kit, no mutations detected exons 8, 9, 13, 17. Twelve (30%) leiomyosarcomas labeling SMA negative KIT. Four these neoplasms well differentiated characterized by weak 8 strong vimentin. None metastasized, higher risk local invasion. Ten (25%) non-GIST/nonleiomyosarcomas that vimentin either S-100 and/or PGP 9.5. These most likely represent neurogenic differentiation resembling Schwann cells perineurial endoneurial fibroblasts, respectively.