The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice.
作者： N. Muslu , A. B. Turhan , G. Eskandari , A. Atici , O. G. Ozturk
关键词:
摘要: Increased bilirubin formation and decreased conjugation play an important role in the pathogenesis of newborn jaundice. Although physiologic jaundice is seen most newborns, there are many risk factors that affect severity duration hyperbilirubinemia. The latest studies showed frequency neonatal have been increased when mutations gene coding UDP-glucuronosyltransferase(UGT)1A1 coexist with other factors. Healthy term newborns weighing over 2500 g. were included this study. patient group consisted 107 either total level 15 mg dl −1 within 7 days or 5 after age. control 55 levels physiological ranges. We investigated promoter region [thymine-adenine(TA)]7 polymorphism UGT1A1 gene. Factors which might cause pathologic prolonged coexisting also investigated. 6/7 genotype was found to be 11% 13% group. difference between groups not statistically significant. (TA)7 allele 0.069 it concluded a factor for
oup.com
oxfordjournals.org
sci-hub.se 参考文章(23)
Meredith L Porter, Beth L Dennis, Hyperbilirubinemia in the term newborn. American Family Physician. ,vol. 65, pp. 599- 606 ,(2002)
, Neonatal Jaundice and Kernicterus Pediatrics. ,vol. 108, pp. 763- 765 ,(2001) , 10.1542/PEDS.108.3.763
S. Aono, H. Keino, Y. Yamada, Y. Adachi, T. Nanno, E. Uyama, O. Koiwai, H. Sato, Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome The Lancet. ,vol. 345, pp. 958- 959 ,(1995) , 10.1016/S0140-6736(95)90702-5
Yoshihiro Maruo, Kashiro Nishizawa, Hiroshi Sato, Yukio Doida, Morimi Shimada, Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism. Pediatrics. ,vol. 103, pp. 1224- 1227 ,(1999) , 10.1542/PEDS.103.6.1224
John D. Bancroft, Bill Kreamer, Glenn R. Gourley, Gilbert syndrome accelerates development of neonatal jaundice The Journal of Pediatrics. ,vol. 132, pp. 656- 660 ,(1998) , 10.1016/S0022-3476(98)70356-7
Hiroshi Sato, Yukihiko Adachi, Osamu Koiwai, The genetic basis of Gilbert's syndrome The Lancet. ,vol. 347, pp. 557- 558 ,(1996) , 10.1016/S0140-6736(96)91266-0
Michael Kaplan, Cathy Hammerman, Paul Renbaum, Gaya Klein, Ephrat Levy-Lahad, Gilbert's syndrome and hyperbilirubinaemia in ABO-incompatible neonates The Lancet. ,vol. 356, pp. 652- 653 ,(2000) , 10.1016/S0140-6736(00)02610-6
Sarah McCue Horwitz, Pamela Owens, Mark D. Simms, Specialized Assessments for Children in Foster Care Pediatrics. ,vol. 106, pp. 59- 66 ,(2000) , 10.1542/PEDS.106.1.59
M. Kaplan, P. Renbaum, E. Levy-Lahad, C. Hammerman, A. Lahad, E. Beutler, Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 12128- 12132 ,(1997) , 10.1073/PNAS.94.22.12128
Kazuhiro Akaba, Toshiyuki Kimura, Ayako Sasaki, Saori Tanabe, Tohru Ikegami, Motoya Hashimoto, Hitoshi Umeda, Hiroshi Yoshida, Kazuo Umetsu, Hitoshi Chiba, Isao Yuasa, Kiyoshi Hayasaka, Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Iubmb Life. ,vol. 46, pp. 21- 26 ,(1998) , 10.1080/15216549800203512