Actions of Hydrogen Sulfide on Sodium Transport Processes across Native Distal Lung Epithelia (Xenopus laevis)

摘要: Hydrogen sulfide (H2S) is well known as a highly toxic environmental chemical threat. Prolonged exposure to H2S can lead the formation of pulmonary edema. However, mechanisms how facilitates edema are poorly understood. Since be enhanced by an impaired clearance electrolytes and, consequently, fluid across alveolar epithelium, it was questioned whether may interfere with transepithelial electrolyte absorption. Electrolyte absorption electrophysiologically measured native distal lung preparations (Xenopus laevis) in Ussing chambers. The epithelia decreased net This due impairment amiloride-sensitive sodium transport. inhibited activity Na+/K+-ATPase lidocaine-sensitive potassium channels located basolateral membrane epithelium. Inhibition these transport molecules diminishes electrochemical gradient which necessary for osmotically clearance, interference epithelial machinery provides mechanism enhances H2S-exposed lungs.