PWE-108 Staining and dysplasia status in barrett’s oesophagus; a retrospective study

摘要: Introduction p53 immuno-staining may be a useful adjunct in the histopathological assessment of dysplasia status Barrett’s Oesophagus. In particular, “significant” or “non-significant” pattern staining discriminating feature cases that are otherwise “indefinite for dysplasia”, potentially helping to up- down-stage these difficult so as facilitate further management. Method We conducted retrospective analysis practice and outcome (dysplasia state) oesophageal biopsies taken over four-year period between 2009 2013 at one major UK hospital. Results A total 486 were identified had undertaken 2013. Sizeable numbers stained from 2011 onwards, with number increasing annually year time considered. parallel this increase practice, we observed decrease proportion classed indefinite dysplasia; 26.8 % those 2011, 18.4 by The fall was accompanied rise showing no (from 21.1 50.7 2013), 35.2 20.2 low-grade; 12.7 5.9 high-grade), same period. also appeared correlate well final status. Namely, 91 without which documented non-significant staining, 85.3 low-grade above significant staining. Conclusion would appear standard evaluation Oesophagus help reduce dysplasia” mandate unnecessary follow-up endoscopies. Further studies prospective design required support conclusion. Disclosure Interest None Declared