Studies towards the Stereoselective Electrophilic Amination of Carbanions

摘要: A rapid development of novel and more efficient amination methods has been recorded during the past decade, mostly regarding electrophilic amination. There are only few for reagent-controlled stereoselective compared to those based on chiral substrates or catalysts. An effective reagent allows greater method flexibility, due high availability prochiral nucleophilic substrates. In present work reactivity three types enantiomerically pure reagents (N-lithiated N-pinenyl hydroxylamines, [alpha]-chloronitroso camphor mannofuranose derivatives, 1-deoxy-2,3:5,6-di-O-isopropylidene-1-nitro-[alpha]-D-mannofuranose) towards carbon nucleophiles (enolates allyl organometallic compounds) was investigated, with aim provide a valuable synthesis [alpha]-amino ketones acids.