New insights into the pathogenesis and treatment of anthrax toxin-induced shock

摘要: Inhalational Bacillus anthracis infection is a leading bioterrorist health threat in the US today. Lethal (LeTx) and edema toxin production are key to virulent effects of this lethal bacteria. Recent insights into structure function these toxins have increased understanding both pathogenesis treatment anthrax. These binary type comprised protective antigen necessary for their cellular uptake either or factors, toxigenic moieties. Primary receptors been identified processing completed clarified. Consistent with ability factor cleave mitogen activated protein kinase kinases, evidence indicates that an excessive inflammatory response does not contribute shock LeTx. Rather, immunosuppressive LeTx could promote infection; however, direct endothelial dysfunction may important role due studies show fa...