Hsp70 expression and function during gametogenesis.

作者: David J. Dix

DOI: 10.1379/1466-1268(1997)002<0073:HEAFDG>2.3.CO;2

关键词:

摘要: The dramatic transformations in nuclear content and cellular organization that occur during gametogenesis require unique regulation execution of the mitotic meiotic cell cycle, apoptotic death, DNA recombination repair, differentiation. These processes are accompanied by constitutive developmentally regulated expression a number hsp70 genes encoding 70 kDa heat shock proteins (Hsp70), including several hsp70s whose is to male germ cells. Examining function Hsp70s cells has provided significant insights into mechanisms gene Hsp70 protein function, as well developmental gametogenesis.

参考文章(50)
S Z Domanico, D C DeNagel, J N Dahlseid, J M Green, S K Pierce, Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. Molecular and Cellular Biology. ,vol. 13, pp. 3598- 3610 ,(1993) , 10.1128/MCB.13.6.3598
David J. Dix, Myra Rosario-Herrle, Hideo Gotoh, Chisato Mori, Eugenia H. Goulding, Cheri V. Barrett, E.M. Eddy, Developmentally regulated expression of Hsp70-2 and a Hsp70-2/lacZ transgene during spermatogenesis. Developmental Biology. ,vol. 174, pp. 310- 321 ,(1996) , 10.1006/DBIO.1996.0076
CarolineM. Milner, R.Duncan Campbell, Polymorphic analysis of the three MHC-linked HSP70 genes. Immunogenetics. ,vol. 36, pp. 357- 362 ,(1992) , 10.1007/BF00218042
D. J. Dix, J. W. Allen, B. W. Collins, C. Mori, N. Nakamura, P. Poorman-Allen, E. H. Goulding, E. M. Eddy, Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 3264- 3268 ,(1996) , 10.1073/PNAS.93.8.3264
Chisato Mori, Noriko Nakamura, David J. Dix, Makio Fujioka, Soichi Nakagawa, Kohei Shiota, Edward M. Eddy, Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp70‐2 knockout mice Developmental Dynamics. ,vol. 208, pp. 125- 136 ,(1997) , 10.1002/(SICI)1097-0177(199701)208:1<125::AID-AJA12>3.0.CO;2-5
Midori Matsumoto, Hirokazu Fujimoto, Cloning of a hsp70-related gene expressed in mouse spermatids Biochemical and Biophysical Research Communications. ,vol. 166, pp. 43- 49 ,(1990) , 10.1016/0006-291X(90)91909-C