Asymmetric transfer hydrogenation of α,β-unsaturated, α-tosyloxy and α-substituted ketones

摘要: Abstract Asymmetric transfer hydrogenation of cyclic and acyclic α,β-unsaturated ketones catalysed by η 6 - p -cymene/ruthenium(II) 5 -pentamethylcyclopentadienyl/rhodium(III) complexes have been investigated. Cyclic appeared to be more suitable substrates for the synthesis enantiomerically pure allylic alcohols than do ketones. A proposed mechanism formation 4-phenyl-[1,3]-dioxolan-2-one from α-tosyloxy- halo-substituted acetophenones is discussed. The results further investigations into reduction a range α-tosyloxyacetophenones dynamic kinetic resolution α-substituted presented.