Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer
作者： Michelle J. Lee , Nan Jin , Jennifer R. Grandis , Daniel E. Johnson
DOI: 10.1016/J.BBAMCR.2020.118679
关键词:
摘要: Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly morbid, genetically unstable disease derived from the mucoepithelium of upper aerodigestive tract. Recent characterization this has implicated PI3K-Akt-mTOR pathway as one most frequently dysregulated pathways. As such, there are several classes PI3K inhibitors currently undergoing clinical trials. In article, we review pathway, mutations in HNSCC, drugs that target PI3K, impact these agents on GSK-3 signaling axes, ongoing trials evaluating inhibitors, challenges using clinic. This article part Special Issue entitled: related kinases cancer, neurological other disorders edited by James McCubrey, Agnieszka Gizak Dariusz Rakus.
sci-hub.se 参考文章(112)
Noor EMBI, Dennis B. RYLATT, Philip COHEN, Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle FEBS Journal. ,vol. 107, pp. 519- 527 ,(2005) , 10.1111/J.1432-1033.1980.TB06059.X
Anthony C Nichols, David A Palma, Winsion Chow, Susan Tan, Chandheeb Rajakumar, Giananthony Rizzo, Kevin Fung, Keith Kwan, Brett Wehrli, Eric Winquist, James Koropatnick, Joe S Mymryk, John Yoo, John W Barrett, High Frequency of Activating PIK3CA Mutations in Human Papillomavirus–Positive Oropharyngeal Cancer Archives of Otolaryngology-head & Neck Surgery. ,vol. 139, pp. 617- 622 ,(2013) , 10.1001/JAMAOTO.2013.3210
C.J. Vlahos, W.F. Matter, K.Y. Hui, R.F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry. ,vol. 269, pp. 5241- 5248 ,(1994) , 10.1016/S0021-9258(17)37680-9
K. Salim, M. J. Bottomley, E. Querfurth, M. J. Zvelebil, I. Gout, R. Scaife, R. L. Margolis, R. Gigg, C. I. Smith, P. C. Driscoll, M. D. Waterfield, G. Panayotou, Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. The EMBO Journal. ,vol. 15, pp. 6241- 6250 ,(1996) , 10.1002/J.1460-2075.1996.TB01014.X
J. Y. Lee, J. A. Engelman, L. C. Cantley, Biochemistry. PI3K charges ahead. Science. ,vol. 317, pp. 206- 207 ,(2007) , 10.1126/SCIENCE.1146073
Smitha R. Georgy, Michael Cangkrama, Seema Srivastava, Darren Partridge, Alana Auden, Sebastian Dworkin, Catriona A. McLean, Stephen M. Jane, Charbel Darido, Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma Journal of the National Cancer Institute. ,vol. 107, pp. 1- 13 ,(2015) , 10.1093/JNCI/DJV152
Bhumsuk Keam, Soyeon Kim, Yong-Oon Ahn, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo, None, In vitro anticancer activity of PI3K alpha selective inhibitor BYL719 in head and neck cancer. Anticancer Research. ,vol. 35, pp. 175- 182 ,(2015)
Heidy Sierra, Miguel Cordova, Chih-Shan Jason Chen, Milind Rajadhyaksha, Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study Journal of Investigative Dermatology. ,vol. 135, pp. 612- 615 ,(2015) , 10.1038/JID.2014.371
Richard A. Brown, Jan Domin, Alexandre Arcaro, Michael D. Waterfield, Peter R. Shepherd, Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. Journal of Biological Chemistry. ,vol. 274, pp. 14529- 14532 ,(1999) , 10.1074/JBC.274.21.14529
Calum Sutherland, What Are the bona fide GSK3 Substrates International Journal of Alzheimer's Disease. ,vol. 2011, pp. 505607- 505607 ,(2011) , 10.4061/2011/505607