Fluorometric Screening Method for Detecting Benzodiazepines in Blood and Urine
作者： James C Valentour , Joseph R Monforte , Beverly Lorenzo , Irving Sunshine
DOI: 10.1093/CLINCHEM/21.13.1976
关键词:
摘要: We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to respective benzophenones converted highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) blood semiquantitatively evaluated compared results of gas-chromatographic determinations.
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