Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients

摘要: She started imatinib (400 mg daily) because of interferon resistance and intolerance. After 3 weeks on imatinib, she presented with a pruriginous maculopapular exanthema in the abdomen both legs. was treated 1% cyclosporin A cream, to 4 times per day. 48 hours, an initial response seen, less erythema pruritus. continuous treatment way described, cutaneous lesions completely disappeared 30 days. Patient 2, 63-year-old male chronic-phase CML diagnosed months earlier, switched therapy cytogenetic interferon.After first week, he that affected arms, legs, abdomen. He cream same schedule as previous patient, complete resolution after 2 months. As mentioned, none patients required corticosteroids, administration maintained at dosage during time skin treatment. Serial blood determinations disclosed undetectable levels, so we conclude absorption through minimal or null while it exerts its pharmacologic action locally. disappearance reactions induced by stopped maintaining administration. No new have been observed either patient since time, follow-up period 24 The exact mechanism is controversial. Some report direct effect Langerhans cells, 5 other experimental papers inhibition T cells measured vitro mixed skin‐cell lymphocyte reaction.6 We think this small experience could be expanded future, more are being different indications (such first-line CML) drug expected. In way, perhaps cyclosporinA‐based local compared type creams, like commercially available corticosteroid-containing creams. This approach also tested for associated drugs antibiotics) localized liquenoid chronic graft-versus-host disease.