Fatty Acid Biosynthesis

摘要: Fatty acid biosynthesis and membrane lipid formation represent major metabolic energy commitments for growing bacterial cells. Some prokaryotic organisms are capable of incorporating exogenous fatty acids into their membranes; however, extracellular not incorporated lipopolysaccharide acyl moieties in gram-negative bacteria typified by Escherichia coli . Thus supplementation cannot compensate the absence de novo production. Since is absolutely required cell membranes walls, a unique inhibitor this branch metabolism would be an effective antibiotic. Antibiotics that target currently use. The general perception mammalian synthase systems so similar site-directed inhibitors block both classes organisms. Recent advances understanding E. system indicate there discrete differences between synthases can exploited to develop antibiotics specifically inhibit growth but do impair