Prevalence and risk factors of renal tubular acidosis after kidney transplantation.

摘要: OBJECTIVE: To asses the prevalence of post-transplant renal tubular acidosis (RTA) and its associated risk factors. METHODS: A cross-sectional study was conducted on 100 live related transplant recipients, with a duration more than one year an estimated GFR > 40 ml/min/1.73m2. Patients acute graft rejection within last 6 months, unstable function, urinary tract infection diarrhoea were excluded. Renal Tubular Acidosis diagnosed basis plasma bicarbonate, venous pH, urine serum anion gap measurements. RESULTS: Out patients (74 male, 26 female) RTA observed in (29 11 female). had lower (65.87 +/- 12.35 versus 74.23 14.8 ml/min/1.73m2, P = 0.004) higher number previous rejections. Lower bicarbonate chloride (108.2 3.19 105.72 3.9 mEq/L, 0.001) potassium concentration (3.95 0.53 vs 3.61 0.46 mg/dl, 0.001). Higher phosphorous level (3.46 0.71 0.59 mg/dl non-RTA, 0.045) but total calcium concentrations found RTA. Intake angiotensin converting enzyme inhibitors (ACE 1) development Calcineurin inhibitor (CNI) therapy not increased likelihood While no difference noted sex, age, pre-transplant dialysis duration, post period, body mass index albumin levels. CONCLUSION: There is high recipients. In most patients, this subclinical does require treatment.