Long non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b.
作者： Chao Shang , Bin Lang , Cheng Ngok Ao , Lirong Meng
关键词:
摘要: Endometrial carcinoma is the most common malignant tumor of female genital tract worldwide. TUSC7 (tumor suppressor candidate 7) an antisense long non-coding RNA and downregulated acts as a potential in several tumors. In this study, low expression was confirmed endometrial tissues associated with high pathological stages carcinoma, which revealed that might be involved tumorigenesis progression carcinoma. Moreover, cell lines resistant to CDDP Taxol lower than sensitive lines, indicated level positively correlated response patients chemotherapy Taxol. upregulation inhibited proliferation, blocked cells at G1 phase, advanced apoptosis sensitivity HEC1A/CR line. Furthermore, miR-23b upregulated negatively TUSC7. pull-down assay could specifically silence line; target gene MiR-23b mostly reversed TUSC7-induced regulatory effects on summary, underexpressed especially chemotherapy-resistant acted inhibit growth well advance through targeted silencing miR-23b, provide new therapeutic
sagepub.com
sci-hub.se 参考文章(21)
Peng Qi, Mi-die Xu, Xiao-Han Shen, Shu-Juan Ni, Dan Huang, Cong Tan, Wei-Wei Weng, Wei-Qi Sheng, Xiao-Yan Zhou, Xiang Du, Reciprocal repression between TUSC7 and miR-23b in gastric cancer. International Journal of Cancer. ,vol. 137, pp. 1269- 1278 ,(2015) , 10.1002/IJC.29516
Ivan Pasic, Adam Shlien, Adam D. Durbin, Dimitrios J. Stavropoulos, Berivan Baskin, Peter N. Ray, Ana Novokmet, David Malkin, Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. Cancer Research. ,vol. 70, pp. 160- 171 ,(2010) , 10.1158/0008-5472.CAN-09-1902
Wen‑Xin Liu, Xiang‑Yu Liu, HU Yu, Ying Chen, Quan Hao, None, Effect of cyclin-dependent kinase 7 silencing on cisplatin sensitivity in endometrial carcinoma cells Molecular Medicine Reports. ,vol. 11, pp. 1745- 1751 ,(2015) , 10.3892/MMR.2014.2980
Jun Zhang, Tingting Yao, Yaxian Wang, Jin Yu, Yunyun Liu, Zhongqiu Lin, Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21 Cancer Biology & Therapy. ,vol. 17, pp. 104- 113 ,(2016) , 10.1080/15384047.2015.1108496
BENGT SORBE, Prognostic importance of DNA ploidy in non-endometrioid, high-risk endometrial carcinomas Oncology Letters. ,vol. 11, pp. 2283- 2289 ,(2016) , 10.3892/OL.2016.4178
F. Abu Saadeh, R. Langhe, D.M. Galvin, S.A. O Toole, D.M. O'Donnell, N. Gleeson, L.A. Norris, Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy Thrombosis Research. ,vol. 139, pp. 135- 141 ,(2016) , 10.1016/J.THROMRES.2016.01.027
Yufeng Wang, Zhikui Liu, Bowen Yao, Changwei Dou, Meng Xu, Yumo Xue, Linglong Ding, Yuli Jia, Hongyong Zhang, Qing Li, Kangsheng Tu, Yang Jiao, Qingguang Liu, Cheng Guo, Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma. Tumor Biology. ,vol. 37, pp. 11429- 11441 ,(2016) , 10.1007/S13277-016-4892-6
Menglin Cong, Jianmin Li, Rui Jing, Zhenzhong Li, Long non-coding RNA tumor suppressor candidate 7 functions as a tumor suppressor and inhibits proliferation in osteosarcoma. Tumor Biology. ,vol. 37, pp. 9441- 9450 ,(2016) , 10.1007/S13277-015-4414-Y
Shou-Hua Wang, Wen-Jie Zhang, Xiao-Cai Wu, Ming-Di Zhang, Ming-Zhe Weng, Di Zhou, Jian-Dong Wang, Zhi-Wei Quan, Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206 Oncotarget. ,vol. 7, pp. 37857- 37867 ,(2016) , 10.18632/ONCOTARGET.9347
Hongtao Ren, Yali Wang, Baofeng Wang, Zhongwei Wang, Yingying Jin, Xiulong Ma, Downregulation of the long non-coding RNA TUSC7 promotes NSCLC cell proliferation and correlates with poor prognosis American Journal of Translational Research. ,vol. 8, pp. 680- 687 ,(2016)