Immunohistochemical Evaluation of Triple Markers (ER, PR and HER-2/neu) in Carcinoma of the Breast in the North of Iraq.

摘要: assessed immunohistochemically on formalin fixed paraffin embedded tissue of tumor. The pattern expression the triple markers was divided into four groups. results these were correlated with age, tumor size, types and grade lymph node status. Results: Each hormonal receptors (ER PR) expressed in 63.3% cases, while HER-2/neu over found 18% cases. ER+, PR +and HER-2 /neu-ve 56.3% While immunonegative observed 25.8% mean age patients positive ER 57.4 years as opposed to 45.7 among lacking expression. 48 years, which is 10 younger than those who lack size tumors expressing both 3.7 cm versus 5.2 for Tumors strong tended be larger expression, sizes 4.9 4.3cm respectively. An inverse relationship between grading there a direct No statistical significant association detected hormone /neu cases one hand metastasis other hand. Conclusions: breast carcinoma. This associated young at presentation, large high histological In contrast, each statistically correlate histopathological typing,